Histology - color icons2

Histology Articles

Non-Aldehyde Fixatives

By National Diagnostics | September 22, 2011 | Comments Off on Non-Aldehyde Fixatives

Mercury Based Fixatives   Mercurials contain mercuric chloride. Their method of tissue fixation is poorly understood. While not penetrating tissue well and causing some tissue hardness, mercurials are fast and provide excellent nuclear detail. They…

Immunohistochemistry

By National Diagnostics | September 20, 2011 | Comments Off on Immunohistochemistry

Immunohistochemistry is the application of antibody/antigen interactions to provide information about biological systems. The body’s response to the introduction of a foreign agent, known as the immune response, results in the production of antibodies which…

Aldehyde Fixatives

By National Diagnostics | September 20, 2011 | Comments Off on Aldehyde Fixatives

Formaldehyde and glutaraldehyde are the most commonly used aldehyde fixatives. They work by forming cross-links both within and between proteins, particularly between lysine residues. Damage to the tertiary structure of the proteins occurs on a…

Overview of Fixation

By National Diagnostics | September 20, 2011 | Comments Off on Overview of Fixation

To maintain the tissue in as lifelike a state as possible, tissue for analysis is usually placed directly into a fixative solution upon removal from the body. Fixation is normally carried out as soon as…