Version 3.0
Date revised: 4/26/2019
SAFETY DATA SHEET
Conforms to regulation (EC) no. EU 453/2010
SECTION 1 - IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING
1.1 Product Identifier
1.2 Relevant Identified Uses of the Substance/Mixture and Uses Advised Against
Investigational research by professional users
1.3 Details of the Supplier of the Safety Data Sheet
| Manufacturer National Diagnostics 305 Patton Drive Atlanta, GA 30036 (404) 699-2121 (800) 526-3867 info@nationaldiagnostics.com |
1.4 Emergency Telephone Number
ChemTel Inc.
Contract number MIS8894340
1-800 255-3924 (United States, Canada, Puerto Rico & US Virgin Islands)
01-800-099-0731 (Mexico)
400-120-0751 (China)
000-800-100-4086 (India)
1-300-954-583 (Australia)
0-800-591-6042 (Brazil)
+1-813-255-3924 (All other regions)
SECTION 2 - HAZARDS IDENTIFICATION
2.1 Classification of the Substance or Mixture
Classification according to Regulation (EC) No. 1272/2008 [EU-GHS/CLP]
H315 - Skin Corrosion/Irritation (Category 2)
H320 - Serious Eye Damage/Eye Irritation (Category 2B)
H335 - Specific Target Organ Toxicity, Single Exposure (Category 3)
2.2 Label Elements
| GHS Label Elements | ||
 | WARNING H315 - Causes skin irritation. | |
2.3 Other Hazards
None found.
SECTION 3 - COMPOSITION/INFORMATION ON INGREDIENTS
3.2 Mixture
Chemical Names/Description
Solution of Buffer Salts. Other ingredients are less than 1%.
Component List
| Component | % Comp. | CAS # | EC # | 1278/2008 Classification |
|---|---|---|---|---|
| Boric Acid | 2 - 5 | 10043-35-3 | 233-139-2 | H360 |
| Tris-Base | 5 - 10 | 77-86-1 | 201-064-4 | H315, H319, H335 |
SECTION 4 - FIRST AID MEASURES
4.1 Description of First Aid Measures
Inhalation
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
Ingestion
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Call a physician.
Skin
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eyes
Immediately flush eyes with plenty of water for at least fifteen minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
4.2 Most Important Symptoms and Effects, Both Acute and Delayed
Inhalation
Boric Acid:
May be absorbed from the mucous membranes of the respiratory tract, and depending on the amount of exposure could result in symptoms paralleling ingestion.
Tris-Base:
Coughing, shortness of breath.
Ingestion
Boric Acid:
Depending on the amount of exposure, ingestion could result in the development of nausea, vomiting, diarrhea, drowsiness, rash, headache, fall in body temperature, low blood pressure, renal injury, cyanosis, coma, and death. Adult fatal dose reported at 5 to > 30 grams.
Tris-Base:
Symptoms may include nausea, vomiting, and diarrhea. Large oral doses may cause weakness, collapse, blood clotting, and coma. The estimated lethal dose of Tris Base is 50 grams dry solid.
Skin
Boric Acid:
Symptoms of skin absorption parallel inhalation and ingestion.
Tris-Base:
Redness, itching, and pain.
Eyes
Boric Acid:
Redness, itching and pain.
Tris-Base:
Redness, itching, and pain.
4.3 Indication of Any Immediate Medical Attention and Special Treatment Needed
Unknown/not applicable
SECTION 5 - FIRE FIGHTING MEASURES
5.1 Extinguishing media
Water spray, dry chemical, alcohol-resistant foam, or carbon dioxide.
5.2 Special Hazards Arising from the Substance/Mixture
Hazardous Combustion Products
May produce carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride when heated to decomposition.
Hazardous Decomposition Products
May produce carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride when heated to decomposition.
Hazardous Polymerization
Will not occur under normal conditions of use (See Sections 10.4 & 10.5).
5.3 Advice for Firefighters
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatuses with full facepiece operated in the pressure demand or other positive pressure mode.
5.4 Further Information
No data available.
SECTION 6 - ACCIDENTAL RELEASE MEASURES
6.1 Personal Precautions
Wear appropriate protective equipment as speicified in Section 8.
6.2 Environmental Precautions
Prevent discharge into the environment. Dike spills and stop leakage where practical. Do not allow material to enter drains.
6.3 Methods and Materials for Containment and Cleaning Up
Contain and clean up spill immediately. Prevent from entering floor drains. Contain liquids using absorbents. Shovel all spill materials into disposal drum. Scrub spill area with detergent. Flush with copious amounts of water.
6.4 References to Other Sections
For disposal information see Section 13. For protective clothing and equipment see Section 8.
SECTION 7 - HANDLING AND STORAGE
7.1 Precautions for Safe Handling
Avoid contact and inhalation. Do not get in eyes, on skin, on clothing. Wash thoroughly after handling.
7.2 Conditions for Safe Storage (including any incompatibles)
Keep in a tightly closed container, stored in a cooled, dry, ventilated area.
Incompatibles
Boric Acid:
Potassium, acetic anhydride, alkalis, carbonates, and hydroxides.
Tris-Base:
No incompatibility data found.
7.3 Specific End Uses
Investigational research by professional users
SECTION 8 - EXPOSURE CONTROLS/PERSONAL PRECAUTIONS
8.1 Control Parameters
Component: Boric Acid
ACGIH Threshold Limit Value (TLV):
10 mg/m3 total dust
OSHA Permissable Exposure Limit (PEL):
15 mg/m3 total dust
Component: Tris-Base
ACGIH Threshold Limit Value (TLV):
none established
OSHA Permissable Exposure Limit (PEL):
none established
8.2 Exposure Controls
Engineering Controls
A system of local and/or general exhaust is recommended to keep employee exposures low. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source.
Respiratory Protection
For conditions of use where exposure to the dust or mist is apparent, a full-face dust/mist respirator may be worn. For emergencies or instances where the exposure levels are not known, use a full-face positive-pressure, air-supplied respirator.
Eye Protection
Safety glasses.
Skin Protection
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
SECTION 9 - PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on Basic Physical & Chemical Properties
| a. Appearance | Clear colorless solution | b. Odor | None |
| c. Odor Threshold | N.A. | d. pH | 8.3 |
| e. Melting/Freezing Point (oC) | -4 | f. Boiling point (oC) | 104.4 |
| g. Flash Point (oC) | N.A. | h. Evaporation Rate | 1.0 |
| i. Flammability | N.A. | j. Upper/Lower Flammability or Explosive Limits | N.A. |
| k. Vapor Pressure | Water | l. Vapor Density (Air = 1) | N.A. |
| m. Relative Density | 1.16 | n. Water Solubility | Soluble |
| o. Partition Coefficient n-octanol/water | Mixture | p. Autoignition Temperature (oC) | N.A. |
| q. Decomposition Temperature (oC) | Not applicable. | r. Viscosity | No data available. |
| s. Explosive Properties | N.A. | t. Oxidizing Properties | Not an oxidizer |
SECTION 10 - STABILITY AND REACTIVITY
10.1 Reactivity
Not reactive under ordinary conditions of use and storage.
10.2 Chemical Stability
Stable under ordinary conditions of use and storage.
10.3 Possibility of Hazardous Reactions
Will not occur under normal conditions of use (See Sections 10.4 & 10.5).
10.4 Conditions to Avoid
Heat, flames, ignition sources, and incompatibles.
10.5 Incompatible Materials
Boric Acid:
Potassium, acetic anhydride, alkalis, carbonates, and hydroxides.
Tris-Base:
No incompatibility data found.
10.6 Hazardous Decomposition Products
May produce carbon monoxide, carbon dioxide, nitrogen oxides and hydrogen chloride when heated to decomposition.
SECTION 11 - TOXICOLOGICAL INFORMATION
Product LD50 Values
Oral Rat LD50 (mg/kg)
91724
Dermal Rabbit LD50 (mg/kg)
Not available
Component Cancer List Status
| NTP Carcinogen | |||
| Known | Anticipated | IARC Category | |
|---|---|---|---|
| Boric Acid | No | No | None |
| Tris-Base | No | No | None |
Potential Health Effects
Inhalation
Boric Acid
Causes irritation to the mucous membranes of the respiratory tract.
Tris-Base
Causes irritation to the respiratory tract.
Ingestion
Boric Acid
Harmful or fatal if ingested in sufficient volume.
Tris-Base
Causes irritation and reddening to the mucous membranes of the mouth, esophagus, and gastrointestinal tract.
Skin
Boric Acid
Causes irritation to the skin.
Tris-Base
Causes irritation to the skin.
Eyes
Boric Acid
Causes irritation to the eyes.
Tris-Base
Causes irritation to the eyes.
Carcinogenicity
Boric Acid
Not listed as a carcinogen by NTP or IARC.
Tris-Base
Not listed as a carcinogen by NTP or IARC.
Mutagenicity
Boric Acid
No information found.
Tris-Base
No information found.
Reproductive Toxicity
Boric Acid
Studies of dogs and rats have shown that infertility and damage to testes can result from acute or chronic ingestion of boric acid. Evidence of toxic effects on the human reproductive system is inadequate.
Tris-Base
No information found.
Teratogenic Effects
Boric Acid
No information found.
Tris-Base
No information found.
Routes of Entry
Boric Acid
Ingestion and inhalation. Not significantly absorbed through the intact skin. Readily absorbed through damaged or burned skin.
Tris-Base
Ingestion.
Target Organ Statement
Boric Acid
Persons with pre-existing skin disorders or eye problems, or impaired liver, kidney or respiratory function may be more susceptible to the effects of this substance.
Tris-Base
No information available.
SECTION 12 - ECOLOGICAL INFOMATION
12.1 Toxicity
COMPONENT: Boric Acid
| Vertebrates | Invertebrates | Algae | Microorganisms | |
|---|---|---|---|---|
Aquatic Toxicity (ppm unless otherwise noted) | LC50 (Limanda limanda, 72hrs) 75mg/L | LC50 (48hr, Daphnia) 133mg/L | NOEC 50mg/L | EC50:(3hr) 175mg/L |
| Birds | Arthropods | Plants | Microorganisms | |
|---|---|---|---|---|
Terrestrial Environment Toxicity (ppm unless otherwise noted) | No data | NOEC (21day, mortality) 175mg/kg soil | No data | EC50 24-250mg/L |
COMPONENT: Tris-Base
| Vertebrates | Invertebrates | Algae | Microorganisms | |
|---|---|---|---|---|
Aquatic Toxicity (ppm unless otherwise noted) | LC50 460mg/l (Golden ide) | EC50: 59.8 mg/L (Daphnia) | EC50: 473mg/l @ 48 hrs | CE50>1000mg/L (3hrs) |
| Birds | Arthropods | Plants | Microorganisms | |
|---|---|---|---|---|
Terrestrial Environment Toxicity (ppm unless otherwise noted) | No data | No data | No data | No data |
12.2 Persistence and Degradability
Boric Acid
No data
Tris-Base
Readily Biodegradable (>97% degradation at 28 days)
12.3 Bioaccumulative Potential
Boric Acid
No data
Tris-Base
No data
12.4 Mobility in Soil
Boric Acid
logKp 0.34L/kg
Tris-Base
Log Koc 1.57-1.85
12.5 Results of PBT and vPvB Assessment
Boric Acid
Does not apply (inorganic)
Tris-Base
Not a PBT or vPvB
12.6 Other Adverse Effects
Boric Acid
None
Tris-Base
None
SECTION 13 - DISPOSAL CONSIDERATIONS
13.1 Waste Treatment Methods
Offer surplus or non-recyclable product to licensed disposal company. Disposal is subject to user compliance with applicable law and product characteristics at time of disposal. Dispose of packaging as product.
SECTION 14 - TRANSPORT INFORMATION
| ADR/RID | IATA | IMO | DOT | |
|---|---|---|---|---|
| 14.1 UN Number | N.A. | N.A. | N.A. | N.A. |
| 14.2 Shipping Name | Not regulated. | Not regulated. | Not regulated. | Not regulated. |
| 14.3 Hazard Class | N.A. | N.A. | N.A. | N.A. |
| 14.4 Packing Group | N.A. | N.A. | N.A. | N.A. |
| 14.5 Environmental Hazards | N.A. | N.A. | Not regulated | N.A. |
| 14.6 Special Precautions | N.A. | N.A. | N.A. | N.A. |
SECTION 15 - REGULATORY INFORMATION
15.1 Safety, Health and Environmental Regulations/Legislation Specific for the Substance/Mixture
United States
TSCA Regulatory Statement
All intentional ingredients are listed on the TSCA
SARA 311/312 Hazard Categories
| Component | Fire | Pressure | Reactivity | Acute | Chronic |
|---|---|---|---|---|---|
| Boric Acid | No | No | No | Yes | Yes |
| Tris-Base | No | No | No | Yes | No |
Europe
EEC Regulatory
All intentional ingredients are listed on the European EINECS Inventory.
SECTION 16 - OTHER INFORMATION
Revisional Updates
4/26/2019 - Updated Section 1.4
5/29/2015 - Updated Sections 2.1 and 3.2
7/23/2013- Released Version 1.0
NFPA Codes
Health 1 Flammability 0 Reactivity 0
Dangers
Boric Acid
H360 - May damage fertility or the unborn child.
Tris-Base
H315 - Causes skin irritation.
H319 - Causes serious eye irritation.
H335 - May cause respiratory irritation.
MANUFACTURER DISCLAIMER: The information given herein is offered in good faith as accurate, but without guarantee. Conditions of the use and suitability of the product for particular uses are beyond our control. All risks of use of the product are therefore assumed by the user. Nothing is intended as a recommendation for uses which infringe valid patents or as extending license under valid patents. Appropriate warnings and safe handling procedures should be provided to handlers and users.