Date revised: 1/22/2010
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MATERIAL SAFETY DATA SHEET
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Conforms to 93/112/EC and ISO 11014-1
1. Chemical Product and Company Identification
Product Name: |
AccuGel 29:1 - 30% | Product Number: |
EC-851 |
|
Chemical Names/ Description: |
Aqueous solution of acrylamides. |
Manufacturer |
Telephone Numbers | |
| National Diagnostics 305 Patton Drive Atlanta, GA 30338 |
(800) 526-3867 (404) 699-2121 | |
Emergency Number | ||
Chemtrec (800) 424-9300 |
2. Composition/Information on Ingredients
| Component | % Comp. | CAS # | EINECS # | TLV (Units) |
| ACRYLAMIDE | < 30 | 79-06-1 | 201-173-7 | 0.03 mg/m3 (TWA) (skin) for solid |
| BIS-ACRYLAMIDE | < 5 | 110-26-9 | 203-750-9 | 5 mg/m3 (TWA) (skin) for solid |
EEC LABEL SYMBOL AND CLASSIFICATION
 | R: 45-46-24/25-48/23/24/25 May cause cancer. May cause heritable genetic damage. Also toxic in contact with skin and if swallowed. Danger of serious damage to health by prolonged exposure through inhalation, in contact with skin or if swallowed. S: 53-45 Avoid exposure, obtain special instructions before use. In case of accident or if you feel ill, seek medical advice immediately (show the label where possible). |
3. Hazards Identification
Appearance and Odor
Clear, colorless solution.
EMERGENCY OVERVIEW - IMMEDIATE HAZARD
WARNING! HARMFUL IF SWALLOWED. MAY CAUSE ALLERGIC SKIN REACTION. MAY CAUSE EYE IRRITATION. POLYMERIZATION MAY OCCUR FROM EXCESSIVE HEAT OR CONTAMINATION.
EMERGENCY OVERVIEW - CHRONIC HAZARD WARNING:
CHRONIC TOXICITY HAZARD. ACRYLAMIDE MAY CAUSE NERVOUS SYSTEM DAMAGE. ACRYLAMIDE CAUSED CANCER AND MALE REPRODUCTIVE DISORDERS IN LABORATORY ANIMAL TESTS. RISK DEPENDS ON DURATION AND LEVEL OF EXPOSURE.
Potential Health Effects
Inhalation
Inhalation of mist causes irritation to the respiratory tract. Symptoms may parallel ingestion.
Ingestion
Toxic! May cause systemic poisoning. May cause drowsiness, tingling sensations, fatigue, weakness, stumbling, slurred speech, and shaking. May cause central and peripheral nervous system damage. Severe intoxication may cause permanent nerve damage. May affect reproductive system and act as a teratogen.
Skin
May cause irritation and redness. Can be absorbed through the skin causing systemic poisoning; symptoms may parallel ingestion.
Eyes
Acrylamide solutions may cause eye irritation.
Signs and Symptoms of Overexposure
Inhalation
Contact with this material by inhalation of mist may cause nervous system effects. See ingestion effects for more details.
Ingestion
Contact with this material by any route (eyes/skin, inhalation or ingestion) may cause nervous system effects (neurotoxicity). These effects can result from a single overexposure but are more likely to occur after repeated exposures to small amounts over a period of several days or weeks. Signs and symptoms of toxic effects include increased sweating of the hands and feet, numbness, tingling and weakness in the extremeties, unsteady gait and decreased reflexes
Skin
Acrylamide is readily absorbed through unbroken skin. If the exposure route is dermal, the signs and symptoms described above under 'Signs and Symptoms of Overexposure - Ingestion' may be preceded by peeling and redness of skin at the areas of exposure, normally the hands and feet.
Eyes
Contact with this material by eyes may cause nervous system effects. See 'Signs and Symptoms of Overexposure - Ingestion' above for more details.
Carcinogenicity
Acrylamide is suspected as a cancer hazard. May cause cancer. Listed by NTP as a suspected carcinogen. Acrylamide is known to the State of California to cause cancer.
Mutagenicity
Acrylamide was negative in the Ames assay both with and without metabolic activation.
Reproductive Toxicitiy
Acrylamide induced male reproductive toxicity has been demonstrated in Long-Evans rats where given greater than or equal to 15 mg/kg/day acrylamide orally by gavage for five consecutive days. In this study, males receiving greater than or equal to 15 mg/kg/day acrylamide had a reduced fertility index.
Teratogenic Effects
Not Available.
Routes of Entry
Contact with this material by any route of exposure (eye/skin, inhalation or ingestion) may cause serious adverse health consequences.
Target Organ Statement
Not Available.
4. First Aid Measures
Inhalation
Remove to fresh air. If not breathing, give artificial respiration. If breathing is difficult, give oxygen. Call a physician.
Ingestion
Induce vomiting immediately as directed by medical personnel. Never give anything by mouth to an unconscious person. Call a physician.
Skin
Immediately flush skin with plenty of soap and water for at least 15 minutes while removing contaminated clothing and shoes. Get medical attention. Wash clothing before reuse. Thoroughly clean shoes before reuse.
Eyes
Immediately flush eyes with plenty of water for at least fifteen minutes, lifting lower and upper eyelids occasionally. Get medical attention immediately.
5. Fire Fighting Measures
| Flash Point | N.A. | Flammable Limits | N.A. |
| Flash Point Method | N.A. | Autoignition temperature | N.A. |
Extinguishing media
Use media appropriate to the primary cause of fire.
Protective Equipment
In the event of a fire, wear full protective clothing and NIOSH-approved self-contained breathing apparatus with full facepiece operated in the pressure demand or other positive pressure mode.
Hazardous Combustion Products
Thermal decomposition products may include carbon monoxide, carbon dioxide, and hydrocarbons.
Unusual Fire and Explosion Hazards
N.A.
| NFPA Codes: | Health | 2 | Flammability | 1 | Reactivity | 1 |
6. Accidential Release Measures
Steps to be taken in case material is released or spilled
Contain and clean up spill immediately, prevent from entering floor drains. Contain liquids using absorbents. Shovel all spill materials into disposal drum. Scrub spill area with detergent, flush with copious amounts of water.
Waste Disposal Method
Disposal must be made in accordance with applicable federal, state, and local regulations.
Personal Precautions
If water solvent has evaporated, wear NIOSH approved air-purifying respirator.
7. Handling and Storage
Handling
Avoid contact and inhalation. Do not get in eyes, on skin, on clothing. Wash thoroughly after handling. Wear special protective equipment (Sec. 8) where exposures may exceed established levels.
Storage
Keep in a tightly closed container, stored in a cooled, dry, ventilated area. Protect from physical damage. Isolate from incompatible materials (section 10).
Storage Temperature
(20 C)
Disposal
Observe all national, state, and local regulations regarding product disposal. Containers of this material may be hazardous when empty since they retain product residues (dust, solids).
8. Exposure Controls/Personal Protection
Airborne Exposure Limits
| Component: ACRYLAMIDE | |
| ACGIH Threshold Limit Value (TLV): | 0.03 mg/m3 (TWA) (skin) for solid |
| OSHA Permissable Exposure Limit (PEL): | 0.3 mg/m3 (TWA) (skin) for solid |
Engineering Controls
A system of local and/or general exhaust is recommended to keep employee exposures below the Airborn Exposure Limits. Local exhaust ventilation is generally preferred because it can control the emissions of the contaminant at its source.
Respiratory Protection
If exposure limits are exceeded, wear a full-face respirator with organic vapor cartridge and high efficiency dust mist filter. Beyond fifty times exposure limits or when exposure levels are not known, wear a full-face piece positive pressure respirator.
Eye Protection
Use chemical safety goggles and/or a full face shield where splashing is possible. Maintain eye wash fountain and quick-drench facilities in work area.
Skin Protection
Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact.
Other Control Measures
Weekly examinations for skin peeling of hands and fingers. Comments: Stress good personal cleanliness and housekeeping to prevent skin contact. Wear clean work clothing daily. Do not home launder.
9. Physical Properties
Boiling point |
220 F |
Evaporation Rate |
1.0
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Melting point |
N.A. |
Solubity in water
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Soluble
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Vapor pressure (mmHg) |
Water |
pH
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Neutral
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Vapor density (Air = 1) |
N.A. |
Specific gravity (H2O = 1)
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1.07
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% volatile by volume |
70 |
10. Stability and Reactivity
Stability
Stable under ordinary conditions of use and storage.
Conditions to Avoid
Heat, shock, UV light, and incompatibles.
Hazardous Decomposition Products
Upon heating, may produce carbon dioxide, carbon monoxide, and hydrogen.
Hazardous Polymerization
May occur
Incompatibles
ACRYLAMIDE:
Acrylamide reacts with acids, oxidizing agents, and bases. Spontaneously reacts with hydroxyl-, amino-, and sulfhydryl- containing compounds. Avoid vinyl polymerization initiators or contamination with aluminum, iron, copper, brass, and bronze.
BIS-ACRYLAMIDE:
Strong bases, strong acids, and oxidizing agents.
11. Toxicological Information
Product LD50 Values
| AccuGel 29:1 - 30% | Oral Rat LD50 (mg/kg): | 330-1330 |
| AccuGel 29:1 - 30% | Dermal Rabbit LD50 (mg/kg): | 2913 |
Component Cancer List Status
| NTP Carcinogen | |||
| Known | Anticipated | IARC Category | |
| ACRYLAMIDE | No | Yes | 2A |
| BIS-ACRYLAMIDE | No | No | None |
12. Ecological Information
ACRYLAMIDE
When pure acrylamide is released into the soil, this material may biodegrade to a moderate extent. When released into the soil, this material is expected to leach into groundwater. This material is not expected to significantly bioaccumulate. When released into the air, this material may be removed from the atmosphere to a moderate extent by wet deposition. For pure acrylamide, the material is not expected to be toxic to aquatic life. The LC50/96-hour values for fish are over 100 mg/l.
BIS-ACRYLAMIDE
No information found.
13. Disposal Considerations
Observe all national, state, and local regulations regarding product disposal. Containers of this material may be hazardous when empty since they retain product residues (dust, solids).
14. Transport Information
D.O.T.
Proper Shipping Name: Not Regulated
Hazard Class: N.A.
UN Number: N.A.
Packing Group: N.A.
Hazard Class: N.A.
UN Number: N.A.
Packing Group: N.A.
I.A.T.A.
Proper Shipping Name: Not Regulated
Hazard Class: N.A.
UN Number: N.A.
Packing Group: N.A.
Hazard Class: N.A.
UN Number: N.A.
Packing Group: N.A.
I.M.O.
Proper Shipping Name: Not Regulated
Hazard Class: N.A.
UN Number: N.A.
Packing Group: N.A.
Hazard Class: N.A.
UN Number: N.A.
Packing Group: N.A.
15. Regulatory Information
United States
TSCA Regulatory Statement
All intentional ingredients are listed on the TSCA Inventory.
SARA 311/312 Hazard Categories
| Component | Fire | Pressure | Reactivity | Acute | Chronic |
| ACRYLAMIDE | No | No | No | Yes | Yes |
| BIS-ACRYLAMIDE | No | No | No | Yes | Yes |
Europe
EEC Regulatory
All intentional ingredients are listed on the European EINECS Inventory.
EEC LABEL SYMBOL AND CLASSIFICATION
| R: 45-46-24/25-48/23/24/25 May cause cancer. May cause heritable genetic damage. Also toxic in contact with skin and if swallowed. Danger of serious damage to health by prolonged exposure through inhalation, in contact with skin or if swallowed. S: 53-45 Avoid exposure, obtain special instructions before use. In case of accident or if you feel ill, seek medical advice immediately (show the label where possible). |
16. Other Information
| NFPA Codes: | Health | 2 | Flammability | 1 | Reactivity | 1 |
MANUFACTURER DISCLAIMER: The information given herein is offered in good faith as accurate, but without guarantee. Conditions of the use and suitability of the product for particular uses are beyond our control. All risks of use of the product are therefore assumed by the user. Nothing is intended as a recommendation for uses which infringe valid patents or as extending license under valid patents. Appropriate warnings and safe handling procedures should be provided to handlers and users.